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Неинвазивный клинический анализ крови

A new non-invasive spectroscopic method has been developed, based on absolute hemoglobin, cytochrome and water concentration measurements in tissue. The method was implemented in the newly designed HemoSpec-2000.

The HemoSpec is based on a 2048-pixel single channel fiberoptic spectrometer, a tungsten light source and a reflection probe with holder. The system is integrated in a 19” industrial mobile equipment carrier with a PC-based industrial workstation and touch-screen TFT-LCD display.

Optionally the HemoSpec can be configured with a double beam 2048-pixel fiber-optic spectrometer, a combined deuterium- tungsten light source and a special reflection-probe.

Applications

The HemoSpec can be used for following applications in which continuous measurement of oxygen saturation, concentration of total, oxygenated and deoxygenated hemoglobin needs to be done. Optionally available are concentration measurements of total and reduced cytochrome aa3. Also water measurements and the concentration of NADH can be obtained. The data are registered and displayed in continuous mode on-line.

The HemoSpec has been implemented successfully in the following fields:

On request we can send you copies of one of the following articles:

1. Rehrborn, H.-J., Steinberg, F., Jungmann, H., Schietzel, M., Streffer, C. (1995):

Noninvasively NIR-Reflectance-Spectroscopy of Cytochromes in Organs and Tumors. Radiation Research (1985 -1995), Congress Proceedings; Vol. 1 :Congress Abstracts, 187; Wьrzburg

2. Steinberg, F., Jungmann, H., Rцhrborn, H.-J., Schietzel, M., Streffer, C. (1995):

Noninvasive Oxygen Measurement In Tumors With A New Wide Range Scanner On NIR Reflection Spectroscopy Radiation Research (1985 -1995), Congress Proc.; Vol. 1; Congress Abstracts, 188; Wьrzburg

3. Steinberg, F., Rцhrborn, H.-J., Otto, T., Lubold K., Peschke, B. Streffer, Ch., (1996):

NIR reflection measurements of hemoglobin and cytochrome aa3 - correlation to oxygen consumption and energy metabolism - preclinical and clinical data, ISOTT, 19th - 23rd August 1996, Dundee, Scotland

4. Steinberg, F., Rцhrborn, H.-J., Scheufler, K.M., Asgari, S., Trost, H.A., Seifert, V. Stolke, D., Streffer, (1996):

NIR reflection spectroscopy based oxygen measurements and therapy monitoring in brain tissue and intracranial neoplasm - correlation’s to MRI and angiographic data. ISOTT, 19th - 23rd August 1996, Dundee, Scotland

5. Steinberg, F., Rцhrborn, H.-J., Otto, T., Scheufler. K.M and Streffer, Ch., (1997):

NIR reflection measurements of hemoglobin and cytochrome aa3 - Correlation to oxygen consumption and energy metabolism - preclinical and clinical data. Oxygen Transport to Tissue XIX, 69-77, New York 1997

6. Steinberg, F., Rцhrborn, H.-J., Scheufler, K.M., Asgari, S., Trost, H.A., Seifert, V. Stolke, D.,Streffer, (1996):

NIR reflection spectroscopy based oxygen measurements and therapy monitoring in brain tissue and intracranial neoplasm - Correlation’s to MRI and angiographic data. Oxygen Transport to Tissue XIX, 553 - 560, New York 1997

7. Asgari, S., Rцhrborn, H.J., Schдfer, H. and Stolke,D. (1999)

In Vivo Measurement of Cytochrome as a Intracellular Oxygen Parameter and Temporary focal Ischemia in Rabbit Brain Zentralbl. Neurochir.Suppl. 1999; 83

8. Asgari, S., Dцrfler, A., Rцhrborn, H.-J., Forsting, M. and Stolke,D. (2000)

In Vivo Measurement of Cytochrome as Intracellular Oxygen Parameter and Temporary Focal Cerebral Ischemia in the Rat, Journal of Cerebral Bloodflow and Metabolism (to be printed)